Product Spec Sheet

Healthy joints and ligaments are never appreciated until one or more becomes a problem. Then, we experience pain, swelling and loss of flexibility. In its worst form, joint illness cripples.

How does it happen?
During our lifetime, factors such as aging, arthritis, diet, injuries, and just plain "wear and tear" can result in joint disease in varying degrees. In fact, 80% of those over 40 show signs of arthritis!

Liquid Vitamins: The Wave of the Future

The human body has two major types of joints:
* Cartilaginous (pelvis) - provides cartilage and cushion where our bones are separated.
* Synovial (shoulders, hands and knees) - these joints are cushioned by cartilage and are surrounded by fluids that allow for maximum flexibility.

Benefits Revealed by Extensive Studies
Extensive studies have revealed that specific, natural nutrients can support joint health. These research studies provide the basis for our FlexeoPlus formula, which supplies specific compounds on which the research was done. Proven benefits include:
- Improved joint flexibility
- Cartilage growth stimulation
- A decrease in joint pain
- Potential connective tissue improvement.

Regain Your Joy
Why live with the pain of the past when you can replace it with joy? Whether happily walking on the beach, enjoying athletics again, painlessly opening a jar, or simply playing with your grandchildren, enjoy the thankful benefits many others have after using FlexeoPlus!

Dual Engineered! FlexeoPlus is designed as a stand-alone, joint-support product. However, it can also be used to compliment calcium supplements. This is especially true of OsteoProCare, with which FlexeoPlus is formulated to work synergistically to improve the effectiveness of both products. Both products are in liquid form and have all the advantages that liquids have over solid forms.

For More Information
* Nutrition Facts
* Efficacy of a New Class of Agents (Glucosamine Hydrochloride and Chondroitin Sulfate)
* Ipriflavone: An Important Bone-Building Isoflavone
* Ipriflavone for Osteoporosis
* GLUCOSAMINE SAVES JOINTS: New Trial Finds Measurable Arthritis Improvement

GENERAL DESCRIPTION: FlexeoPlus is a proprietary formula of ingredients proven through numerous scientific studies to improve joint health. See the attached references. FlexeoPlus is a highly concentrated formula. It is “dual engineered.” It can be a stand-alone, joint-support product, and it can also be used to compliment calcium supplements. This is especially true of OsteoProCare, with which FlexeoPlus is formulated to work synergistically, to improve the effectiveness of both products.

THE BIOLIQUID ADVANTAGE: FlexeoPlus is a liquid formula. This is significant because nutrients in solid forms may have an absorption rate of only up to 20%, whereas liquids can have up to 98% absorption. FlexeoPlus has a technological edge with the BioLiquid Advantage, which has various functional components:
• The first is the concentration factor. No other liquid joint-support product has the concentration of beneficial ingredients as does FlexeoPlus. FlexeoPlus is four times more concentrated than other products. A proprietary, “sequentially miscible” process of combining key ingredients achieves this concentration. As with cooking recipes, the sequence of adding ingredients is important to the outcome.
• The second functional component is the proper way to make fat and water-soluble elements miscible. This allows FlexeoPlus to contain ipriflavone (fat soluble) in a solution with water-soluble ingredients without separation occurring.
• The third functional component is the use of enhancement nutrients. Zinc, and vitamins C and K-1 enhance the utilization of the beneficial ingredients. Additionally, ipriflavone enhances the utilization of calcium.
• The fourth functional component is the method of stabilizing the formula. Integrating numerous active ingredients within a liquid medium creates a formidable stability challenge. FlexeoPlus benefits from exceptional shelf life, which is especially impressive given the high concentration of beneficial ingredients.

INGREDIENTS: Dozens of studies have revealed specific, natural compounds that can support joint health. These studies provide the basis for our FlexeoPlus formula, which supplies the nutrients on which the research was done. Proven benefits include improved joint flexibility, cartilage growth stimulation, a decrease in joint pain, and may even improve connective tissue such as tendons and ligaments.
• Glucosamine – This compound has been scientifically proven to benefit joint health. Glucosamine stimulates the essential cartilage building blocks called glycosaminoglycans and proteoglycans. 1,2,3
• MSM (Methyl Sulfonyl Methane) – MSM has also been clinically proven to support joint health. 4,5,6
• Ipriflavone – Has been shown to improve bone density with, or without, calcium. 7,8,9
• Zinc & Vitamins C & K-1 – All of these nutrients improve the effectiveness of the primary ingredients. 10,11,12,13

Product Spec Sheet

Suggested Use: After shaking the bottle, mix 4 droppers full (3/4 teaspoon) into OsteoProCare, or
any juice.

REFERENCES
1. “Glucosamine sulfate for osteoarthritis.” da Camara CC, Dowless GV. Ann Pharmacother 1998 May
32:5 580-7.
2. “Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee.” Houpt JB,
McMillan R, Wein C, Paget-Dellio SD. J Rheumatol 1999 Nov 26:11 2423-30.
3. “Glucosamine sulphate: a controlled clinical investigation in arthrosis.” D’Ambrosio E, Casa B, Bompani
R, Scali G, Scali M. Pharmatherapeutica 1981 2:8 504-8.
4. Dietary and pharmaceutical uses of methyl-sulfonylmethane and compositions comprising it. United
States Patent 4,559,329. Herschler, December 17, 1985.
5. Dietary products and uses comprising methylsulfonylmethane. United States Patent 4,863,748.
Herschler, September 5, 1989.
6. “Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins.” Richmond VL. Life
Sci 1986 Jul 21 39:3 263-8.
7. “Ipriflavone” Kitatani K, Morii H. Nippon Rinsho 1998 Jun 56:6 1537-43.
8. “A double blind, placebo-controlled trial of ipriflavone for prevention of postmenopausal spinal bone
loss.” Agnusdei D, Crepaldi G, Isaia G, Mazzuoli G, Ortolani S, Passeri M, Bufalino L, Gennari C.
Calcif Tissue Int 1997 Aug 61:2 142-7.
9. “Effect of chronic treatment with ipriflavone in postmenopausal women with low bone mass.” Gennari
C, Adami S, Agnusdei D, Bufalino L, Cervetti R, Crepaldi G, Di Marco C, Di Munno O, Fantasia L, Isaia
GC, Mazzuoli GF, Ortolani S, Passeri M, Serni U, Vecchiet L. Calcif Tissue Int 1997 61 Suppl 1: S19-22.
10. “Effect of zinc deficiency on bone collagenase and collagen turnover.” Starcher BC, Hill CH, Madaras
JG. J Nutr 1980 Oct 110:10 2095-102.
11. “Influence of zinc on synthesis and the accumulation of collagen in early granulation tissue.” Tengrup
I, Ahonen J, Zederfeldt B. Surg Gynecol Obstet 1981 Mar 152:3 323-6.
12. “Regulation of collagen synthesis in human dermal fibroblasts in contracted collagen gels by ascorbic
acid, growth factors, and inhibitors of lipid peroxidation.” Gessin JC, Brown LJ, Gordon JS, Berg
RA. ExpCell Res 1993 Jun 206:2 283-90.
13. “The function and metabolism of vitamin K.” Olson RE. Annu Rev Nutr 1984 4: 281-337.